Detection of human papillomavirus type 18 oncogen E7 in patients with prostate cancer
https://doi.org/10.17650/1726-9784-2019-18-1-37-41
Abstract
Introduction . High prostate cancer (PC) incidence rates testify to importance of research into genesis of the given disease and means of its prevention. The item of oncogenic human papillomaviruses (HPVs) participance in PC origination is still being the subject of debates. If association of PC with HPV is proven prophylaxis of the given disease becomes possible by means of inoculating boys with the vaccines made for cervical cancer (CC) prevention.
Objective: to test whether prostate tissues surgically removed from PC patients harbor oncogen E7 of HPV18 – the second most common HPV type responsible for CC.
Materials and methods . The study was carried out on prostate glands of 17 PC patients surgically treated in N.N. Blokhin National Medical Research Center of Oncology. Detection of HPV18 oncogen E7 was done by polymerase chain reaction. To elevate polymerase chain reaction sensitivity DNA was isolated from homogeneous cell populations collected by means of microdissections from cryopreserved PC specimens.
Results . Amplification products corresponding to HPV18 oncogen E7 were registered in tests from 2 PC patients.
Conclusion . HPV18 oncogen E7 was detected in surgically removed prostate tissues of 2 PC patients. In the aggregate with our previous result (7 HPV16-positive PC cases in the same group of 17 patients) the given result enables one to presume participance of oncogenic HPVs in PC genesis. The problem deserves further study.
About the Authors
G. M. Volgareva
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478,
Russian Federation
24 Kashirskoe Shosse, Moscow 115478,
V. D. Ermilova
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478,
Russian Federation
24 Kashirskoe Shosse, Moscow 115478,
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Review
For citations:
Volgareva G.M., Ermilova V.D. Detection of human papillomavirus type 18 oncogen E7 in patients with prostate cancer. Russian Journal of Biotherapy. 2019;18(1):37-41. (In Russ.) https://doi.org/10.17650/1726-9784-2019-18-1-37-41
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