МИКРОСАТЕЛЛИТНАЯ НЕСТАБИЛЬНОСТЬ И КАРЦИНОМА ЖЕЛУДКА. ОБЗОР ЛИТЕРАТУРЫ
Аннотация
Рак желудка (РЖ) – широко распространенная злокачественная опухоль с плохим прогнозом. Последние исследования характеристик генома позволяют рассматривать РЖ как гетерогенное заболевание, представленное различными биологическими подтипами, каждый из которых имеет свои специфические свойства и признаки с различным прогнозом. Микросателлитная нестабильность (МСН) – эпигенетическое молекулярное нарушение, известное во многих опухолях. Роль МСН в РЖ, как прогностическая, так и предиктивная, не вполне ясна. Частая встречаемость (от 10 до 22 %) РЖ с МСН требует более интенсивного изучения ее роли в данной опухоли. Данный обзор посвящен современным данным литературы, касающимся клинических, морфологических, прогностических и предиктивных свойств МСН в РЖ.
Об авторах
Д. Л. Ротин
ГБУЗ «Городская клиническая больница им. С. П. Боткина Департамента здравоохранения г. Москвы»
Россия
Россия, 125284 Москва, 2‑й Боткинский проезд, 5
Россия
Россия, 125284 Москва, 2‑й Боткинский проезд, 5
О. П. Паклина
ГБУЗ «Городская клиническая больница им. С. П. Боткина Департамента здравоохранения г. Москвы»
Россия
Россия, 125284 Москва, 2‑й Боткинский проезд, 5
Россия
Россия, 125284 Москва, 2‑й Боткинский проезд, 5
И. О. Тинькова
ГБУЗ «Городская клиническая больница им. С. П. Боткина Департамента здравоохранения г. Москвы»
Россия
Россия, 125284 Москва, 2‑й Боткинский проезд, 5
Россия
Россия, 125284 Москва, 2‑й Боткинский проезд, 5
Д. Н. Греков
ГБУЗ «Городская клиническая больница им. С. П. Боткина Департамента здравоохранения г. Москвы»
Россия
Россия, 125284 Москва, 2‑й Боткинский проезд, 5
Россия
Россия, 125284 Москва, 2‑й Боткинский проезд, 5
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Для цитирования:
Ротин Д.Л., Паклина О.П., Тинькова И.О., Греков Д.Н. МИКРОСАТЕЛЛИТНАЯ НЕСТАБИЛЬНОСТЬ И КАРЦИНОМА ЖЕЛУДКА. ОБЗОР ЛИТЕРАТУРЫ. Российский биотерапевтический журнал. 2019;18(4):17-24. https://doi.org/10.17650/1726-9784-2019-18-4-17-24
For citation:
Rotin D.L., Paklina O.V., Tin’kova I.O., Grekov D.N. MICROSATELLITE INSTABILITY AND GASTRIC CARCINOMA. REVIEW OF THELITERATURE. Russian Journal of Biotherapy. 2019;18(4):17-24. (In Russ.) https://doi.org/10.17650/1726-9784-2019-18-4-17-24
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