MICROSATELLITE INSTABILITY AND GASTRIC CARCINOMA. REVIEW OF THELITERATURE
https://doi.org/10.17650/1726-9784-2019-18-4-17-24
Abstract
Carcinoma of the stomach is wide spread malignancy with the poor prognosis. Recent investigations of the genome features let to consider this tumor as heterogeneous lesion, presenting different biological subtypes. Each of those subtypes has its own definitive characteristics including difference in prognosis. Microsatellite instability (MSI) – epigenetic molecular abnormality known in many tumors. The role of MSI in the carcinoma of stomach, prognostic as well predictive, is still not clear. High incidence (10 up to 22 %) of MSI in carcinoma of stomach requires performing more extensive studying of this malignancy. The present review is dedicated to recent data of the literature, concerning clinical, morphological, prognostic and predictive features of MSI in the carcinoma of stomach.
About the Authors
D. L. Rotin
S. P. Botkin City Clinical Hospital
Russian Federation
5 Second Botkinskyi Proyezd, Moscow 125284, Russia
Russian Federation
5 Second Botkinskyi Proyezd, Moscow 125284, Russia
O. V. Paklina
S. P. Botkin City Clinical Hospital
Russian Federation
5 Second Botkinskyi Proyezd, Moscow 125284, Russia
Russian Federation
5 Second Botkinskyi Proyezd, Moscow 125284, Russia
I. O. Tin’kova
S. P. Botkin City Clinical Hospital
Russian Federation
5 Second Botkinskyi Proyezd, Moscow 125284, Russia
Russian Federation
5 Second Botkinskyi Proyezd, Moscow 125284, Russia
D. N. Grekov
S. P. Botkin City Clinical Hospital
Russian Federation
5 Second Botkinskyi Proyezd, Moscow 125284, Russia
Russian Federation
5 Second Botkinskyi Proyezd, Moscow 125284, Russia
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Review
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Rotin D.L., Paklina O.V., Tin’kova I.O., Grekov D.N. MICROSATELLITE INSTABILITY AND GASTRIC CARCINOMA. REVIEW OF THELITERATURE. Russian Journal of Biotherapy. 2019;18(4):17-24. (In Russ.) https://doi.org/10.17650/1726-9784-2019-18-4-17-24
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