Smart polymers in drug delivery: a perspective in pharmaceutical technology
E. V. Blynskaya,
K. V. Alekseyev, 
D. V. Yudina,
V. K. Alexseev,
S. V. Tishkov,
V. V. Bueva,
S. V. Minaev,
V. V. Adzhienko,
A. A. Ivanov
D. V. Yudina,
V. K. Alexseev,
S. V. Tishkov,
V. V. Bueva,
S. V. Minaev,
V. V. Adzhienko,
A. A. Ivanov https://doi.org/10.17650/1726-9784-2019-18-2-15-20
Abstract
Polymers have already been recognized as promising materials in many areas of life including pharmaceutical technology. A wide range of polymer properties such as providing controlled release of APIs, enhancing permeation and protection of APIs from mucosal enzymes is now successfully using worldwide in producing soft and solid dosage forms. It is now recognized that a significant portion of the polymer research ongoing in the world is related with a new group of polymer properties such as «shape memory system» and “self-folding”. This review focuses on “smart” – polymers properties that could be a promising tool in developing smart delivery systems.
About the Authors
E. V. Blynskaya
Zakusov Institute of Pharmacology.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
K. V. Alekseyev
Zakusov Institute of Pharmacology; Moscow medical university “REAVIZ”.
Russian Federation
8 Baltiyskaya St., Moscow 125315; build. 2, 2 Krasnobogatyrskaya St., Moscow 107564.
Russian Federation
8 Baltiyskaya St., Moscow 125315; build. 2, 2 Krasnobogatyrskaya St., Moscow 107564.
D. V. Yudina
Zakusov Institute of Pharmacology.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
V. K. Alexseev
Zakusov Institute of Pharmacology.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
S. V. Tishkov
Zakusov Institute of Pharmacology.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
V. V. Bueva
Zakusov Institute of Pharmacology.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
S. V. Minaev
Zakusov Institute of Pharmacology.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
V. V. Adzhienko
Zakusov Institute of Pharmacology.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
A. A. Ivanov
Zakusov Institute of Pharmacology.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
Russian Federation
8 Baltiyskaya St., Moscow 125315.
References
1. Алексеев К.В., Блынская Е.В., Тихонова Н.В. и др. Полимеры в технологии создания лекарственных форм с модифицированным высвобождением. Российский химический журнал 2010;6:87-93. [Alekseev K.V., Blynskaya E.V., Tihonova N.V. et al. Polymers in modified-release drug delivery technology. Rossiysky khimichesky zhurnal = Russian Journal of General Chemistry 2010;6:87-93 (In Russ.)].
2. Юдина Д.В., Блынская Е.В., Алексеев К.В., Марахова А.И. Использование полимеров для улучшения растворимости фармацевтических субстанций в твердых лекарственных формах. Известия Академии наук. Серия химическая 2018;5:787-91. [Yudina D.V., Blynskaya E.V., Alekseev K.V., Marahova A.I. Polymers for the enhancement of solubility of pharmaceutical substances in solid drug formulations. Izvestiya Akademii nauk. Seriya khimicheskaya = Bulletin of the Russian Academy of Sciences. Division of Chemical Sciences 2018;5:787-91. (In Russ.)].
3. Блынская Е.В., Алексеев К.В., Аляутдин Р.Н. Перспективы развития фармацевтической нанотехнологии. Российский химический журнал 2010;6:38-44. [Blynskaya E.V., Alekseev K.V., Alyautdin R.N. Prospects for the development of pharmaceutical nanotechnology. Rossiysky khimichesky zhurnal = Russian Journal of General Chemistry 2010;6:38-44. (In Russ.)].
4. Алексеев К.В., Аляутдин Р.Н., Блынская Е.В. и др. Основные направления в технологии получения наноносителей лекарственных веществ. Вестник новых медицинских технологий 2009;2(16):142-5. [Alekseev K.V., Alyautdin R.N., Blynskaya E.V. et al. The basic directions in technology of reception of nanocarriers of medical substances. Vestnik novykh meditsinskikh tekhnologiy = Journal of New Medical Technologies 2009;2(16):142—5. (In Russ.)].
5. Тазина Е.В., Костин К.В., Оборотова Н.А. Особенности инкапсулирования лекарственных препаратов в липосомы (обзор). Химико-фармацевтический журнал 2011;8(45):30—40. [Tazina E.V., Kostin K.V., Oborotova N.A. Specific Features of drug encapsulation in liposomes (a review). Khimiko-farmatsefticheskiy zhurnal = Pharmaceutical Chemistry Journal 2011; 8(45):30-40 (In Russ.)]. DOI: 10.30906/ 0023-1134-2011-45-8-30-40.
6. Sokolowski W., Metcalfe A., Hayashi S. et al. Medical applications of shape memory polymers. Biomed Mater 2007;2(1):23-7. DOI: 10.1088/1748-6041/2/1/S04.
7. Razzaq M.R., Anhalt M., Frorman L. et al. Mechanical spectroscopy of magnetite filled polyurethane shape memory polymers. Mat Sci and A-STRUCT 2007;471:57-62. DOI: 10.1016/j.msea.2007.03.059.
8. Guan J., He H., Hansford D.J. et al. Self-Folding of Three-Dimensional Hydrogel Microstructures. J Phys Chem B 2005;109(49):23134—7. DOI: 10.1021/jp054341g.
9. Fernandes R., Gracias D.H. Self-folding polymeric containers for encapsulation and delivery of drugs. Adv Drug Deliv Rev 2012;6:1579-89. DOI: 10.1016/j.addr.2012.02.012.
10. Ionov L., Zakharenko S., Stoychev G. et al. Soft Microorigami: self-Folding polymer films. Soft Matter 2011;7:6786— 91. DOI: 10.1039/C1SM05476G.
11. He H., Guan J., Lee J.L. An oral delivery device based on self-folding hydrogels. J Control Release 2006;110(2):339-46. DOI: 10.1016/j.jconrel.2005.10.017.
12. Nagahama K., Ueda Y., Ouchi T., Ohya Y. Biodegradable shape-memory polymers exhibiting sharp thermal transitions and controlled drug release. Biomacromolecules 2009;10:1789-94. DOI: 10.1021/bm9002078.
13. Serrano M.C., Carbajal L., Ameer A.G. Novel Biodegradable Shape-Memory Elastomers with Drug-Releasing Capabilities. Advanced Materials 2011;23:2211-5. DOI: 10.1002/adma.201004566.
14. Fernandes R., Gracias D.H. Self-folding polymeric containers for encapsulation and delivery of drugs. Adv Drug Deliv Rev 2012;64(14):1579-89. DOI: 10.1016/j.addr.2012.02.012.
15. He H.Y., Guan J.J., Lee J.L. An oral delivery device based on self-folding hydrogels. J Control Release 2006;110:339-46. DOI: 10.1016/j.jconrel.2005.10.017.
16. James H.P., John R., Alex A. Smart polymers for the controlled delivery of drugs - a concise overview. Acta Pharm Sin B 2014;4(2):120-7. DOI: 10.1016/j.apsb.2014.02.005.
17. Smela E., Inganas O., Lundstrom I. Controlled Folding of Micrometer-Size Structures. Sci 1995;268(5218):735—8. DOI: 10.1126/science.268.5218.1735.
18. Luchnikov V., Sydorenko O., Stamm M. Self-Rolled Polymer and Composite Polymer/Metal Micro- and Nanotubes with Patterned Inner Walls. Adv Mater 2005;17:1177-82. DOI: 10.1002/adma.200401836.
19. Lakkadwala S., Nguyen S., Nesamony J. et al. Smart Polymers in Drug Delivery. Excipient Applications in Formulation Design and Drug Delivery. Springer International Publishing Switzerland 2015;169-99. DOI: 10.1007/978-3-319-20206-8_7.
20. Shim T.S., Kim S.H., Heo C.J. et al. Controlled origami folding of hydrogel bilayers with sustained reversibility for robust microcarriers. Angew Chem Int Ed Engl 2012;51(6):1420—3. DOI: 10.1002/ange.201106723.
21. Hunter A.C., Moghimib S.M. Smart polymers in drug delivery: a biological perspective Polym Chem 2017;8:41-51. DOI: 10.1039/C6PY00676K.
22. Jamal M., Zarafshar A.M., Gracias D.H. Differentially photo-crosslinked polymers enable self-assembling microfluidics. Nat Commun 2011;2:527. DOI: 10.1038/ncomms1531.
23. Azam A., Laflin K.E., Jamal M. et al. Self-folding micropatterned polymeric containers. Biomed Microdevevices 2011;13:51-8. DOI: 10.1007/s10544-010-9470-x.
24. Py C., Reverdy P., Doppler L. et al. Capillary Origami: Spontaneous Wrapping of a Droplet with an Elastic Sheet. Phys Rev Lett 2007;98:156103. DOI: 10.1103/PhysRevLett.98.156103.
25. Cho J.H., Azam A., Gracias D.H. Three dimensional nanofabrication using surface forces. Langmuir 2010;26(21):16534-9. DOI: 10.1021/la1013889.
26. Py C., Reverdy P., Doppler L. et al. Capillarity induced folding of elastic sheets. Eur Phys J Special Topics 2009;166:67-1. DOI: 10.1140/epjst/e2009-00880-4.
Review
For citations:
Blynskaya E.V., Alekseyev K.V., Yudina D.V., Alexseev V.K., Tishkov S.V., Bueva V.V., Minaev S.V., Adzhienko V.V., Ivanov A.A. Smart polymers in drug delivery: a perspective in pharmaceutical technology. Russian Journal of Biotherapy. 2019;18(2):15-20. (In Russ.) https://doi.org/10.17650/1726-9784-2019-18-2-15-20
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