SMALL GTPASE ARF6 ACTIVATES mTORCl-DEPENDENT SIGNALING PATHWAY AND STIMULATES GLIOBLASTOMA CELL GROWTH
https://doi.org/10.17650/1726-9784-2015-14-2-91-98
Abstract
In this study we first identified role of small GTPase Arf6 in stimulation of proliferation and autonomous growth of human glioblastoma cells. We revealed that Arf6 activates the mTOR complex 1 (mTORCl) and this process is appeared to be an alternative mechanism of mTORC1-signaling activation, independent of PI3K/Akt-signaling pathway. We also showed that Arf6 is a negative regulator of protein kinase ERK1/2 in glioblastoma cells.
Keywords
пролиферация,
Arf6,
mTORCl,
p70S6K1,
ERKl/2,
линии клеток глиобластомы,
proliferation,
Arf6,
mTORC1,
p70S6K1,
ERK1/2,
glioblastoma cells
About the Authors
A. Yu. Zhuravskaya
ФГБУ «РОНЦ им. Н.Н. Блохина»
Russian Federation
Russian Federation
A. V. Komelkov
ФГБУ «РОНЦ им. Н.Н. Блохина»
Russian Federation
Russian Federation
E. M. Tchevkina
ФГБУ «РОНЦ им. Н.Н. Блохина»
Russian Federation
Russian Federation
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Review
For citations:
Zhuravskaya A.Yu., Komelkov A.V., Tchevkina E.M. SMALL GTPASE ARF6 ACTIVATES mTORCl-DEPENDENT SIGNALING PATHWAY AND STIMULATES GLIOBLASTOMA CELL GROWTH. Russian Journal of Biotherapy. 2015;14(2):91-98. (In Russ.) https://doi.org/10.17650/1726-9784-2015-14-2-91-98
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