РОЛЬ ЭПИТЕЛИАЛЬНО-МЕЗЕНХИМАЛЬНОГО ПЕРЕХОДА В РЕГУЛЯЦИИ СВОЙСТВ РАКОВЫХ СТВОЛОВЫХ КЛЕТОК СОЛИДНЫХ ОПУХОЛЕЙ
https://doi.org/10.17650/1726-9784-2015-14-4-3-8
Аннотация
Резюме РСК - это субпопуляция трансформированных клеток, которая является возможной причиной устойчивости злокачественных новообразований к терапии, а также рецидивирования и метастазирования опухолей. По этой причине РСК представляются перспективной мишенью для разработки новых подходов к противоопухолевой терапии. Выявлен ряд механизмов, позволяющих трансформированным клеткам приобретать фенотип стволовых, что значительно осложняет лечение злокачественных новообразований. Такими механизмами является вариант эпителиально-мезенхимального перехода (ЭМП) и утрата е-кадгерина, приводящие к образованию в карциномах клеток, обладающих свойствами РСК. Целью данного обзора является рассмотрение возможных механизмов образования РСК в карциномах человека.
Об авторах
М. Д. Фармаковская
ФГБУ «РОНЦ им. Н.Н. Блохина» М3
Россия
Россия
Н. В. Хромова
ФГБУ «РОНЦ им. Н.Н. Блохина» М3
Россия
Россия
В. А. Рыбко
ФГБУ «РОНЦ им. Н.Н. Блохина» М3
Россия
Россия
Павел Борисович Копнин
ФГБУ «РОНЦ им. Н.Н. Блохина» М3
Россия
Россия
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Рецензия
Для цитирования:
Фармаковская М.Д., Хромова Н.В., Рыбко В.А., Копнин П.Б. РОЛЬ ЭПИТЕЛИАЛЬНО-МЕЗЕНХИМАЛЬНОГО ПЕРЕХОДА В РЕГУЛЯЦИИ СВОЙСТВ РАКОВЫХ СТВОЛОВЫХ КЛЕТОК СОЛИДНЫХ ОПУХОЛЕЙ. Российский биотерапевтический журнал. 2015;14(4):3-8. https://doi.org/10.17650/1726-9784-2015-14-4-3-8
For citation:
Farmakovskaya M.D., Khromova N.V., Rybko V.A., Kopnin P.B. THE ROLE OF EPITHELIAL-MESENCHYMAL TRANSITION IN REGULATION OF SOLID TUMORS CANCER STEM CELLS CHARACTERISTICS. Russian Journal of Biotherapy. 2015;14(4):3-8. (In Russ.) https://doi.org/10.17650/1726-9784-2015-14-4-3-8
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