THE PREPARATION FOR INTRAOPERATIVE VISUALIZATION OF «SENTINEL» LYMPH NODES
https://doi.org/10.17650/1726-9784-2015-14-4-93-98
Abstract
We developed the original preparation Lymphotest on the basis of disulphoderivative of diaminotriphenylmet- anic dye, differing from Lymphazurin by positions if sulphogroups in benzene ring - N-[4-[[4-(diethylamino)phenyl] (2,5-disulfophenyl)methylene]-2,5-cyclohexadien-l-ylidene]-N-ethylethanaminium hydroxide, inner salt, sodium salt. The proposed compound practically does not differ by spectrum from Lymphazurin, but is much more accessible and highly lymphotropic. Lymphotest in the form of 1% aqueous solution is characterized by a high diagnostic efficiency when using direct color lymphography, low toxicity (imposed dose exceeded the anticipated maximum dose for a human in 50-1000 times) and has no locally-irritating effect when using subcutaneously.
About the Authors
A. A. Pankratov
Hertsen Moscow Research Institute of Oncology
Russian Federation
Russian Federation
T. N. Andreeva
Hertsen Moscow Research Institute of Oncology
Russian Federation
Russian Federation
R. I. Yakubovskaya
Hertsen Moscow Research Institute of Oncology
Russian Federation
Russian Federation
A. D. Kaprin
Hertsen Moscow Research Institute of Oncology
Russian Federation
Russian Federation
A. A. Konarev
State Research Center «NIOPIK»
Russian Federation
Russian Federation
T. V. Yakunina
State Research Center «NIOPIK»
Russian Federation
Russian Federation
E. A. Lukyanets
State Research Center «NIOPIK»
Russian Federation
Russian Federation
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Review
For citations:
Pankratov A.A., Andreeva T.N., Yakubovskaya R.I., Kaprin A.D., Konarev A.A., Yakunina T.V., Lukyanets E.A. THE PREPARATION FOR INTRAOPERATIVE VISUALIZATION OF «SENTINEL» LYMPH NODES. Russian Journal of Biotherapy. 2015;14(4):93-98. (In Russ.) https://doi.org/10.17650/1726-9784-2015-14-4-93-98
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