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Российский биотерапевтический журнал

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ТЕРАПИЯ, НАПРАВЛЕННАЯ НА СТВОЛОВУЮ КЛЕТКУ ОПУХОЛИ: НАДЕЖДЫ И ВОЗМОЖНОСТИ

https://doi.org/10.17650/1726-9784-2016-15-4-8-17

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Аннотация

Фундаментальной проблемой в лечении рака остается идентификация клеток, способных инициировать и поддерживать рост опухоли. До недавнего времени предполагалось, что все клетки опухоли обладают одинаковой способностью инициировать опухоль и формировать метастазы. Сегодня достоверно показано, что такими свойствами обладает небольшая популяция особых клеток, называемых стволовой клеткой опухоли (СКО). СКО - это специфическая опухолевая клетка, долгоживущая и медленно пролиферирующая, способная при трансплантации иммунодефицитным животным инициировать рост опухоли, идентичной исходной. СКО характеризуются чрезвычайной терапевтической устойчивостью, которая в ответ на лечение только возрастает. Регрессия опухоли и длительная ремиссия после лечения зависят от уничтожения этой самой важной части опухолевых клеток. В обзоре обсуждаются пути возникновения опухоли, характерные особенности СКО, ее роль в метастазировании и терапия, направленная на СКО.

Об авторах

Амалия Арташевна Вартанян
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»
Россия


К. А. Барышников
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»
Россия


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Для цитирования:


Вартанян А.А., Барышников К.А. ТЕРАПИЯ, НАПРАВЛЕННАЯ НА СТВОЛОВУЮ КЛЕТКУ ОПУХОЛИ: НАДЕЖДЫ И ВОЗМОЖНОСТИ. Российский биотерапевтический журнал. 2016;15(4):8-17. https://doi.org/10.17650/1726-9784-2016-15-4-8-17

For citation:


Vartanian A.A., Baryshnikov K.A. THERAPIES TARGETING CANCER STEM CELLS OF THE TUMOR: THE ONE AND ONLY HOPE. Russian Journal of Biotherapy. 2016;15(4):8-17. (In Russ.) https://doi.org/10.17650/1726-9784-2016-15-4-8-17

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