REDOX DENDRIMERS

Aim of this work was the synthesis of REDOX-dendrimer core, which is tetraglycidyl ether of pentaerythritol, and a dendron, which is a derivative of anthraquinone. Materials and methods. Analytical and preparative chromatography was carried out on a liquid chromatograph SP 8000 (Spectra-Physics (USA)). Chromatograms were recorded using a UV-detector (Spectra-Physics (USA)) and refractive index detector (Jobin-Ivon (France)). The structure was confirmed by PMR (Bruker WH-360 (Germany)) with an operating frequency of 360 MHz. Monitoring of reactions conducted using HPLC. Results. Derivatives of 2-methylanthraquinone were synthesized and isolated by use of preparative HPLC. Their structure was determined by PMR-spectroscopy. They were used as a dendron in the synthesis of dendrimer. Its toxicity was studied in male mice ВDF1. Redox dendrimers containing methylanthraquinone derivatives in its structure were synthetized. Low toxicity of obtained REDOX-dendrimer was shown. Conclusion. The similarity of REDOX-dendrimer structure with doxorubicin and its low toxicity provides background for further study of its antitumor activity.

REDOX-дендример, производные 2-метилантрахинона, тетраглицидиловый эфир пентаэритрита, высокоэффективная жидкостная хроматография, токсикология, REDOX-dendrimer, derivatives 2-methylanthraquinone, tetraglycidyl ether of pentaerythritol, HPLC, toxicology

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