TECHNOLOGICAL APPROACHES TO IMPROVING THE PROCESS LYOPHILIZATION OF PROTEIN AND PEPTIDE DRUGS
https://doi.org/10.17650/1726-9784-2017-16-1-6-11
Abstract
Lyophilization of protein and peptide anticancer drugs is a promising method to create a stable and effective parenteral dosage forms. This article reviews the main problems encountered during lyophilization of protein and peptide drugs, and describes the best practices for solving these problems. The ways of optimization and improvement of the freeze-drying are given. Temperatures to improve the properties and prevent the destruction of the cake lyophilizatiе are suggested.
About the Authors
E. V. Blynskaya
V.V. Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
S. V. Tishkov
V.V. Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
K. V. Alekseev
Medical University “REAVIZ”
Russian Federation
Russian Federation
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Review
For citations:
Blynskaya E.V., Tishkov S.V., Alekseev K.V. TECHNOLOGICAL APPROACHES TO IMPROVING THE PROCESS LYOPHILIZATION OF PROTEIN AND PEPTIDE DRUGS. Russian Journal of Biotherapy. 2017;16(1):6-11. (In Russ.) https://doi.org/10.17650/1726-9784-2017-16-1-6-11
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