Role of tumor-like multipotent mesenchymal stromal cells in rheumatoid arthritis
https://doi.org/10.17650/1726-9784-2017-16-3-21-23
Abstract
Multipotent mesenchymal stromal/stem cells (MSCs) are regarded as a stable, safe and easily available source of precursor cells for purposes of regenerative medicine. However, under repeated replication in tissue reparation processes and action of inflammatory mediators, aged MSCs may be transformed and obtain certain tumor-cell characteristics. The present review deals with the MSCs role in pathogenesis of rheumatoid arthritis. High proliferation speed, lack of contact inhibition and invasive growth of transformed MSCs is an important mechanism of cartilage destruction in rheumatoid arthritis.
About the Authors
M. V. Kiselevskiy
N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
N. Yu. Anisimova
N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
I. O. Chikileva
N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
R. Ya. Vlasenko
N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Yu. I. Dolzhikova
N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
S. M. Sitdikova
N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
F. S. Senatov
National University of Science and Technology“MISIS”
Russian Federation
Russian Federation
K. C. Yang
School of Dental Technology, College of Oral Medicine
Russian Federation
Russian Federation
J. C. Yang
Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering, Taipei Medical University
Russian Federation
Russian Federation
References
1. Horwitz E.M., Le Blanc K., Dominici M. et al. International Society for Cellular Therapy. Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy 2005;7:393-5. DOI: 10.1080/14653240500319234.
2. Ullah I., Subbarao R.B., Rho G.J. Human mesenchymal stem cells -current trendsand future prospective. Biosci Rep 2015/35/art:e00191. DOI: 10.1042/BSR20150025.
3. Wakitani S., Saito T., Caplan A.I. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 1995;18: 1417-26. DOI: 10.1002/mus.880181212.
4. Xu W., Zhang X., Qian H. et al. Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro. Exp Biol Med 2004;229:623-31.
5. Tang D.Q., Wang Q., Burkhardt B.R. et al. In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but longterm culture running risk of malignant transformation. Am J Stem Cells 2012;1:114-27.
6. Gabr M.M., Zakaria M.M., Refaie A.F. et al. Insulin-producing cells from adult human bone marrow mesenchymal stem cells control streptozotocin-induced diabetes in nude mice. Cell Transplant 2013;22:133-45. DOI: 10.3727/096368912X647162.
7. Rengasamy M., Gupta P.K., Kolkundkar U. et al. Preclinical safety & toxicity evaluation of pooled, allogeneic human bone marrow-derived mesenchymal stromal cellsIndian. J Med Res 2016;6:852-
8. DOI: 10.4103/ijmr. IJMR_1842_15.
9. Firestein G.S. Evolving concepts of rheumatoid arthritis. Nature 2003;423:356-61. DOI: 10.1038/nature01661.
10. Pap T., Muller-Ladner U., Gay R.E., Gay S. Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res 2000;2:361-7. DOI: 10.1186/ar113.
11. Edwards J.C. Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis. Arthritis Res 2000;2:344-47. DOI: 10.1186/ar110.
12. Firestein G.S. Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum 1996;39:1781-90. DOI: 10.1002/art.1780391103.
13. Muller-Ladner U., Kriegsmann J., Gay R.E., Gay S. Oncogenes in rheuma toid arthritis. Rheum Dis Clin North Am 1995;21:675-90.
14. Lafyatis R., Remmers E.F., Roberts A.B. et al. Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. J Clin Invest 1989;83:1267-76.
15. Yamasaki S., Nakashima T., Kawakami A. et al. Cytokines regulate fibroblast-like synovial cell differentiation to adipocytelike cells. Rheumatology (Oxford) 2004;43:448-52.
16. Li X., Makarov S.S. An essential role of NF-B in the tumor-like phenotype of arthritic synoviocytes. PNAS 2006;103 (46):17437. DOI: 10.1007/s10753-015-0220-3.
17. Geiler T., Kriegsmann J., Keyszer G.M. et al. A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice. Arthritis Rheum 1994;37:1664-71.
18. Müller-Ladner U., Kriegsmann J., Franklin B.N. et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 1996;49:1607-15.
Review
For citations:
Kiselevskiy M.V., Anisimova N.Yu., Chikileva I.O., Vlasenko R.Ya., Dolzhikova Yu.I., Sitdikova S.M., Senatov F.S., Yang K.C., Yang J.C. Role of tumor-like multipotent mesenchymal stromal cells in rheumatoid arthritis. Russian Journal of Biotherapy. 2017;16(3):21-23. (In Russ.) https://doi.org/10.17650/1726-9784-2017-16-3-21-23
Views:
342
Email this article 
