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Современные методы лечения рака молочной железы у пожилых

https://doi.org/10.17650/1726-9784-2017-16-3-24-31

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Аннотация

Течение рака молочной железы у пожилых имеет ряд особенностей, что связано с повышенным риском развития различного рода осложнений. Рекомендации по лечению рака молочной железы у пожилых носят противоречивый характер - от радикальных операций до консервативной терапии. На сегодняшний день нет конкретных клинических рекомендаций в отношении данной возрастной группы, что делает эту статью актуальной.

Об авторах

Д. А. Рябчиков
ФГБУ«НМИЦ онкологии им. Н.Н. Блохина» Минздрава России
Россия


Н. К. Чепелова
ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)
Россия


И. К. Воротников
ФГБУ«НМИЦ онкологии им. Н.Н. Блохина» Минздрава России
Россия


Д. А. Денчик
ФГБУ«НМИЦ онкологии им. Н.Н. Блохина» Минздрава России
Россия


Список литературы

1. Злокачественные новообразования в России 2015 (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М.: МНИОИ им. П.А. Герцена - филиал ФГБУ «НМИРЦ» Минздрава России, 2017. 250 с.

2. Senkus E., Kyriakides S., Ohno S. et al. Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2015;26(5):8-30. DOI: 10.1093/annonc/mdv298. PMID: 26314782.

3. Maher M., Dreyfus H., Campana F. et al. Management of breast cancer in the elderly. Eur J Cancer Care (Engl) 1995;4(2):75-9. PMID: 7599875.

4. van de Water W., Kiderlen M., Bastiaannet E. et al. External validity of a trial comprised of elderly patients with hormone receptor - positive breast cancer. J Natl Cancer Inst 2014;106(4):dju051. DOI: 10.1093/jnci/dju051. PMID: 24647464.

5. Мудраковская Э.В., Горелик С.Г. Структура сопутствующей патологии у больных пожилого и старческого возраста с урологическими заболеваниями. ВНМТ 2013;(1):101-3

6. Личиницер М.Р. Гормонотерапия РМЖ. Материалы V Российской онкол. конф., 27-29 ноября. М., 2001 С. 23-24.

7. Воротников В.В. Клиникоморфологические особенности и лечение операбельного рака молочной железы у пожилых (>65 лет) женщин. Дис.. канд. мед. наук. СПб., 2016. 110 с.

8. Freedman R.A., Vaz-Luis I., Barry W.T. et al. Patterns of chemotherapy, toxicity, and short-term outcomes for older 3'2017 том 16 | vol. 16 DOI: 10.1007/s10549-014-2968-9. PMID: 24756187.

9. Vaz-Luis I., Keating N.L., Lin N.U. et al. Duration and toxicity of adjuvant trastuzumab in older patients with early-stage breast cancer: a population-based study. J Clin Oncol 2014;32(9):927-34. DOI: 10.1200/JCO.2013.51.1261. PMID: 24516021. PMCID: PMC3948095.

10. Freedman R.A., Hughes M.E., Ottesen R.A. et al. Use of adjuvant trastuzumab in women with human epidermal growth factor receptor 2 (HER2) - positive breast cancer by race/ethnicity and education within the National Comprehensive Cancer Network. Cancer 2013;119(4):839-46. DOI: 10.1002/cncr.27831. PMID: 23011924. PMCID: PMC3565006.

11. Savolt Ä. et al. Eight-year follow up result of the OTOASOR Trial: The Optimal Treatment Of the Axilla - Surgery Or Radiotherapy after positive sentinel lymph node biopsy in early-stage breast cancer. A randomized, single centre, phase III, non-inferiority trial. Eur J Surg Oncol 2017;43(4):672-9. DOI: 10.1016/j.ejso.2016.12.011. PMID: 28139362.

12. de Glas N.A., Kiderlen M., Bastiaannet E. et al. Postoperative complications and survival of elderly breast cancer patients: a FOCUS study analysis. Breast Cancer Res Treat 2013;138(2):561-9. DOI: 10.1007/s10549-013-2462-9. PMID: 23446810.

13. Kiderlen M., de Glas N.A., Bastiaannet E. et al. Impact of comorbidity on outcome of older breast cancer patients: a FOCUS cohort study. Breast Cancer Res Treat 2014;145(1):185-92. DOI: 10.1007/s10549-014-2917-7. PMID: 24676624.

14. Christifano D.N., Fazzino T.L., Sullivan D.K., Befort C.A. Diet Quality of Breast Cancer Survivors after a Six-Month Weight Management Intervention: Improvements and Association with Weight Loss. Nutr Cancer 2016;68(8):1301-8. DOI: 10.1080/01635581.2016.1224368. PMID: 27635676. PMCID: PMC5160017.

15. Schairer C., Gadalla S.M., Pfeiffer R.M. et al. Diabetes, Abnormal Glucose, Dyslipidemia, Hypertension and Risk of Inflammatory and Other Breast Cancer. Cancer Epidemiol Biomarkers Prev 2017;26(6):862-8. DOI: 10.1158/1055-9965.EPI-16-0647. PMID: 28087608.

16. Zhao X.-B., Ren G.-S. Diabetes mellitus and prognosis in women with breast cancer: A systematic review and meta-analysis. Medicine(Baltimore) 2016;95(49):e5602. DOI: 10.1097/MD.0000000000005602. PMID: 27930583. PMCID: PMC5266055.

17. Srokowski T.P., Fang S. Hortobagyi G.N., Giordano S.H. Impact of diabetes mellitus on complications and outcomes of adjuvant chemotherapy in older patients with breast cancer. J Clin Oncol 2009;27(13):2170-6. DOI: 10.1200/JCO.2008.17.5935. PMID: 19307509. PMCID: PMC2674004.

18. Kiderlen M., de Glas N.A., Bastiaannet E. et al. Diabetes in relation to breast cancer relapse and all-cause mortality in elderly breast cancer patients: a FOCUS study analysis. Ann Oncol 2013;24(12):3011-6. DOI: 10.1093/annonc/mdt367. PMID: 24026538.

19. Engels C.C., Kiderlen M., Bastiaannet E. et al. The clinical prognostic value of molecular intrinsic tumor subtypes in older breast cancer patients: A FOCUS study analysis. Mol Oncol 2016;10(4):594-600. DOI: 10.1016/j.molonc.2015.11.002. PMID: 26706834.

20. Daly M.B., Pilarski R., Axilbund J.E. et al. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2015. J Natl Compr Canc Netw 2016;14(2):153-62. PMID: 26850485.

21. Nichols E.M., Cohen R.J., Cheston S.B., Feigenberg S.J. Radiation Therapy in the Elderly with Early Stage Breast Cancer: Review and Role of New Technology. J Nucl Med Radiat Ther 2014;5:204. DOI: 10.4172/2155-9619.1000204.

22. Ryden L., Heibert Arnlind M., Vitols S. et al. Aromatase inhibitors alone or sequentially combined with tamoxifen in postmenopausal early breast cancer compared with tamoxifen or placebo -meta-analyses on efficacy and adverse events based on randomized clinical trials. Breast 2016;26:106-14. DOI: 10.1016/j. breast.2016.01.006. PMID: 27017249.

23. Huang L., Xu A.-M. Short-term outcomes of neoadjuvant hormonal therapy versus neoadjuvant chemotherapy in breast cancer: systematic review and meta-analysis of randomized controlled trials. Expert Rev Anticanc 2017;17(4):327-34. DOI:10.1080/14737140.2017.1301208. PMID: 28271747.

24. Hassett M.J., Silver S.M., Hughes M.E. et al. Adoption of Gene Expression Pro file Testing and Association With Use of Chemotherapy Among Women With Breast Cancer. J Clin Oncol 2012;30(18):2218-26. DOI: 10.1200/JCO.2011.38.5740. PMID: 22585699. PMCID: PMC3397718.

25. Sawaki M., Mukai H., Tokudome N. et al. Safety of adjuvant trastuzumab for HER-2-overexpressing elderly breast cancer patients: a multicenter cohort study. Breast Cancer 2012;19(3):253-8. DOI: 10.1007/s12282-011 -0270-9. PMID: 21526424.

26. Slamon D., Eiermann W., Robert N. et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med 2011;365(14):1273-83. DOI: 10.1056/NEJMoa0910383. PMID: 21991949. PMCID: PMC3268553.

27. Lichtman S.M., Cirrincione C.T., Hurria A. et al. Effect of Pretreatment Renal Function on Treatment and Clinical Outcomes in the Adjuvant Treatment of Older Women With Breast Cancer: Alliance A171201, an Ancillary Study of CALGB/CTSU 49907. J Clin Oncol 2016;34(7):699-705. DOI: 10.1200/JCO.2015.62.6341. PMID: 26755510. PMCID: PMC4872024.

28. von Minckwitz G., Reimer T., Potenberg J. et al. The phase III ICE study: Adjuvant Ibandronate with or without capecitabine in elderly patients with moderate or high risk early breast cancer: JOUR. Cancer Res 2015;75(9 Suppl): 3-4. Abstr.

29. Christman K., Muss H.B., Case L.D., Stanley V. Chemotherapy of metastatic breast cancer in the elderly. The Piedmont Oncology Association experience [see comment]. JAMA 1992;268(1):57-62. PMID: 1608114.

30. Biganzoli L., Wildiers H., Oakman C. et al. Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology(SIOG) and European Society of Breast Cancer Specialists (EUSOMA). Lancet Oncol 2012;13(4):e148-60. DOI:10.1016/S1470-2045(11)70383-7. PMID: 22469125.

31. Engels C.C., Kiderlen M., Bastiaannet E. et al. The clinical value of HER-2 over-expression and PIK3CA mutations in the older breast cancer population: a FOCUS study analysis. Breast Cancer Res Treat 2016;156(2):361-70. DOI: 10.1007/s10549-016-3734-y. PMID: 26968397. PMCID: PMC4819549.

32. Chavez-MacGregor M., Niu J., Zhang N. et al. Cardiac Monitoring During Adjuvant Trastuzumab-Based Chemotherapy Among Older Patients With Breast Cancer. J Clin Oncol 2015;33(19):2176-83. DOI: 10.1200/JCO.2014.58.9465. PMID: 25964256. PMCID: PMC4979214.

33. Tolaney S.M., Barry W.T., Dang C.T. et al. Adjuvant Paclitaxel and Trastuzumab for Node-Negative, HER2-Positive Breast Cancer. N Engl J Med 2015;372(2):134-41. DOI: 10.1056/NEJMoa1406281. PMID: 25564897. PMCID: PMC4313867.

34. Muss H.B., Berry D.A., Cirrincione C.T. et al. Adjuvant Chemotherapy in Older Women with Early-Stage Breast Cancer. N Engl J Med 2009;360(20):2055-65. DOI:10.1056/NEJMoa0810266. PMID: 19439741. PMCID: PMC3082436.

35. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 801 women in 17 randomised trials. Lancet 2011;378(9804):1707-16. DOI: 10.1016/S0140-6736(11)61629-2. PMID: 22019144. PMCID: PMC3254252.

36. Kiderlen M., Bastiaannet E., Walsh P.M. et al. Surgical treatment of early stage breast cancer in elderly: an international comparison. Breast Cancer Res Treat 2012;132(2):675-82. DOI: 10.1007/s10549-011-1892-5. PMID: 22119939. PMCID: PMC3303082.

37. Kiderlen M., Walsh P.M., Bastiaannet E. et al. Treatment strategies and survival of older breast cancer patients - an international comparison between the Netherlands and Ireland. PLoS One 2015;10(2):e0118074. DOI: 10.1371/journal.pone.0118074. PMID: 25646756. PMCID: PMC4315587.

38. Cohen R.J., Li L., Citron W. et al. Improved survival with adjuvant radiation in elderly women with early-stage breast cancer. Int J Radiat Oncol Biol Phys 2012;84(Suppl):33-4.

39. Korah M.P., Sener S.F., Tripathy D. Implications of Omitting Radiation After Breast Conserving Surgery in Elderly Women With Low-risk Invasive Breast Cancer. Int J Radiat Oncol Biol Phys 2017;3(84):34.

40. Kunkler I.H., Williams L.J., Jack W.J. et al. Breast-conserving surgery with or without irradiation in women aged

41. years or older with early breast cancer (PRIME II): a randomised controlled trial. Lancet Oncol 2017;16(3):266-73. DOI: 10.1016/S1470-2045(14)71221-5. PMID: 25637340.

42. Hughes K.S., Schnaper L.A., Bellon J.R. et al. Lumpectomy plus tamoxifen with or without irradiation in women age

43. years or older with early breast cancer: Long-Term Follow-Up of CALGB 9343. J Clin Oncol 2013;31(19):2382-7. DOI: 10.1200/JTO. 2012.45.2615. PMID: 23690420. PMCID: PMC3691356.

44. Giuliano A.E., Hunt K.K., Ballman K.V. et al. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: а randomized clinical trial. JAMA 2011;305(6):569-75. DOI: 10.1001/jama.2011.90. PMID: 21304082. PMCID: PMC5389857.

45. Smith B.D., Bentzen S.M., Correa C.R. et al. Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline. Int J Radiat Oncol Biol Phys 2011;81(1):59-68. DOI: 10.1016/j.ijrobp.2010.04.042. PMID: 20638191.

46. Jagsi R., Griffith K.A., Boike T.P. et al. Differences in the Acute Toxic Effects of Breast Radiotherapy by Fractionation Schedule: Comparative Analysis of Physician-Assessed and Patient-Reported Outcomes in a Large Multicenter Cohort. JAMA Oncol 2015;1(7):918-30. DOI: 10.1001/jamaoncol.2015.2590. PMID: 26247417.

47. Coates A.S., Winer E.P., Goldhirsch A. et al. Tailoring therapies-improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015. Ann Oncol 2015;26(8):1533-46. DOI: 10.1093/annonc/mdv221. PMID: 25939896. PMCID: PMC4511219.

48. Smith B.D., Arthur D.W., Buchholz T.A. et al. Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO). J Am Coll Surg 2009;209(2):269-77. DOI: 10.1016/j.jamcollsurg.2009.02.066. PMID: 19632605.

49. Leonardi M.C., Maisonneuve P., Mastropasqua M.G. et al. How do the ASTRO consensus statement guidelines for the application of accelerated partial breast irradiation fit intraoperative radiotherapy? A retrospective analysis of patients treated at the European Institute of Oncology. Int J Radiat Oncol Biol Phys 2012;83(3):806-13. DOI: 10.1016/j.ijrobp.2011.08.014. PMID: 22245196.

50. Olivotto I.A., Whelan T.J., Parpia S. et al. Interim cosmetic and toxicity results from RAPID: a randomized trial of accelerated partial breast irradiation using three-dimensional conformal external beam radiation therapy. J Clin Oncol 2013;32(31):4038-45. DOI: 10.1200/JCO.2013.50.5511. PMID: 23835717.

51. Najafipour F., Hamouzadeh P., Arabloo J. et al. Safety, effectiveness and economic evaluation of intra-operative radiation therapy: a systematic review. Med J Islam Repub Iran 2015;(29):258. PMID: 26793649. PMCID: PMC4715414.

52. Zur M., Shai A., Leviov M. et al. Short-term complications of intra-operative radiotherapy for early breast cancer. J Surg Oncol 2016;113(4):370-3. DOI: 10.1002/jso.24157. PMID: 26751138.

53. Keshtgar M.R., Williams N.R., Bulsara M. et al. Objective assessment of cosmetic outcome after targeted intra-operative radiotherapy in breast cancer: results from a randomised controlled trial. Breast Cancer Res Treat 2013;140(3):519-25. DOI: 10.1007/s10549-013-2641-8. PMID: 23877341.

54. Fornage B.D., Sneige N., Ross M.I. et al. Small Small (≤2-cm) breast cancer treated with US-guided radiofrequency ablation: feasibility study. Radiology 2004;231(1):215-24. DOI: 10.1148/radiol.2311030651. PMID: 14990810.

55. Chen J., Zhang C., Li F. et al. A meta-analysis of clinical trials assessing the effect of radiofrequency ablation for breast cancer. Onco Targets Ther 2016;9:1759-66. DOI: 10.2147/OTT.S97828. PMID: 27042126. PMCID: PMC4809337.

56. Mauri G., Sconfienza L.M., Pescatori L.C. et al. Technical success, technique efficacy and complications of minimally-invasive imaging-guided percutaneous ablation procedures of breast cancer: A systematic review and meta-analysis. Eur Radiol 2017;27(8):3199-210. DOI: 10.1007/s00330-016-4668-9. PMID: 28050693.

57. Peek M.C., Ahmed M., Napoli A. et al. Minimally invasive ablative techniques in the treatment of breast cancer: a systematic review. Int J Hyperthermia 2016:1 - 12 [Epub ahead of print]. DOI: 10.1080/02656736.2016.1230232. PMID: 27575566.


Для цитирования:


Рябчиков Д.А., Чепелова Н.К., Воротников И.К., Денчик Д.А. Современные методы лечения рака молочной железы у пожилых. Российский биотерапевтический журнал. 2017;16(3):24-31. https://doi.org/10.17650/1726-9784-2017-16-3-24-31

For citation:


Ryabchikov D.A., Chepelova N.K., Vorotnikov I.K., Denchik D.A. Modern methods of treatment of breast cancer in the elderly. Russian Journal of Biotherapy. 2017;16(3):24-31. (In Russ.) https://doi.org/10.17650/1726-9784-2017-16-3-24-31

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