Сytotoxicity of zinc (II) and cadmium (II) iodide complexes with antipyrine, caffeine and phenantroline
https://doi.org/10.17650/1726-9784-2017-16-3-75-78
Abstract
Objective: to study the cytotoxic activity of the zinc (II) and cadmium (II) iodide complexes with antipyrine (AP), caffeine (caf) and 1,10-phenantroline (phen) in comparison with that of free ligands, zinc (II) and cadmium (II) iodides in vitro. Materials and methods. The cytotoxic activity of the zinc (II) and cadmium (II) iodide complexes with AP, caf and phen in comparison with that of free ligands, zinc (II) and cadmium (II) iodides was investigated by methylthiazole tetrazolium assay using 5 human tumor cell lines. Results. It has been found that all 3 cadmium complexes demonstrate cytotoxic activity towards all 5 cell lines with concentration of inhibition of 50 % cell growth 5.5-84.0 mkM. Cytotoxicity of the most active diiodo(1,10-phenantroline)cadmium was slightly above than that of the respective ligand. One zinc-containing complex (diiodo(1,10-phenantroline)zinc) demonstrated significant activity towards 3 cell lines. The Jurkat cells were the most sensitive to studied compounds. Conclusion. It seems that zinc (II) and cadmium (II) iodide complexes with organic ligands are promising ones as potential antitumor drugs for further investigations both in vitro and in vivo.
Keywords
About the Authors
I. S. Golubeva
N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
A. E. Barmashov
N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
A. A. Rudakova
N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
M. A. Baryshnikova
N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
N. S. Rukk
Moscow Technological University
Russian Federation
Russian Federation
A. Yu. Skryabina
Moscow Technological University
Russian Federation
Russian Federation
G. N. Apryshko
N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
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Review
For citations:
Golubeva I.S., Barmashov A.E., Rudakova A.A., Baryshnikova M.A., Rukk N.S., Skryabina A.Yu., Apryshko G.N. Сytotoxicity of zinc (II) and cadmium (II) iodide complexes with antipyrine, caffeine and phenantroline. Russian Journal of Biotherapy. 2017;16(3):75-78. (In Russ.) https://doi.org/10.17650/1726-9784-2017-16-3-75-78
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