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Российский биотерапевтический журнал

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Патологические изменения дендритных клеток при раке

https://doi.org/10.17650/1726-9784-2016-15-4-25-33

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Аннотация

Иммунная система играет особую роль в развитии опухолевого процесса. С одной стороны, она способна бороться с раком с помощью врожденного и приобретенного звеньев, с другой стороны - опухоль может использовать иммунные клетки для защиты от противоопухолевого ответа. Дендритные клетки (ДК) являются основными антигенпредставляющими клетками и поэтому активно участвуют в развитии иммунного ответа на присутствие в организме опухолевых клеток. ДК способны захватывать опухолевые антигены и представлять их Т-клеткам, вызывая тем самым опухолеспецифический Т-клеточный ответ. Однако в большинстве случаев терапия рака c использованием препаратов ДК не позволяет достичь клинически значимого эффекта. Одна из основных причин - неблагоприятное воздействие на ДК микроокружения опухоли. Важным этапом работы по улучшению методов биотерапии с использованием ДК является определение факторов, вызывающих нарушение функций ДК при раке, а восстановление нормальных функций ДК у онкологических больных представляет собой одну из основных задач иммунотерапии рака. В настоящем обзоре рассмотрены основные виды патологических изменений, которые происходят в ДК под влиянием опухоли.

Об авторах

Антон Артурович Кескинов
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России; Университет г. Питтсбург
Россия


М. Р. Щурин
Университет г. Питтсбург
Россия


В. М. Бухман
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России
Россия


З. С. Шпрах
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России
Россия


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Для цитирования:


Кескинов А.А., Щурин М.Р., Бухман В.М., Шпрах З.С. Патологические изменения дендритных клеток при раке. Российский биотерапевтический журнал. 2016;15(4):25-33. https://doi.org/10.17650/1726-9784-2016-15-4-25-33

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Keskinov A.A., Shurin M.R., Bukhman V.M., Shprakh Z.S. PATHOPHYSIOLOGY OF DENDRITIC CELLS IN CANCER. Russian Journal of Biotherapy. 2016;15(4):25-33. (In Russ.) https://doi.org/10.17650/1726-9784-2016-15-4-25-33

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ISSN 1726-9784 (Print)
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